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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Updated: Jun 28, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Oncohaematologic disorders affecting the skeleton in the elderly.

Andrea Baur-Melnyk1, Maximilian Reiser

  • 1Department of Clinical Radiology, University of Munich, Grosshadern, Germany. andrea.baur@med.uni-muenchen.de

Radiologic Clinics of North America
|October 17, 2008
PubMed
Summary

This review covers elderly-specific skeletal oncohematologic disorders, including multiple myeloma and metastatic tumors. It details their radiographic scanning, staging, and prognosis for better patient outcomes.

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Area of Science:

  • Oncohematology
  • Geriatric Medicine
  • Skeletal Pathology

Background:

  • Multiple myeloma, chronic lymphatic leukemia, aplastic anemia, and osteomyelofibrosis are common in the elderly.
  • These conditions involve malignant plasma cell proliferation, bone destruction, or bone marrow failure.
  • Skeletal metastases are frequent in adults, particularly the elderly.

Purpose of the Study:

  • To review oncohematologic disorders affecting the elderly skeleton.
  • To examine radiographic scanning methods, staging, and prognosis for these conditions.

Main Methods:

  • Literature review of oncohematologic disorders impacting the elderly skeleton.
  • Analysis of radiographic imaging techniques for diagnosis.
  • Evaluation of staging systems and prognostic factors.

Main Results:

  • Multiple myeloma involves plasma cell proliferation leading to bone destruction.
  • Skeletal metastases are common malignant bone tumors in the elderly.
  • Chronic lymphatic leukemia, aplastic anemia, and osteomyelofibrosis present unique hematologic and skeletal challenges.

Conclusions:

  • Accurate diagnosis and staging are crucial for managing elderly patients with skeletal oncohematologic disorders.
  • Understanding radiographic findings aids in prognosis and treatment planning.
  • This review provides a comprehensive overview for clinicians managing these complex cases.