Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of platelet activating factor on reticuloendothelial system function.

M Trop1, E J Schiffrin, E A Carter

  • 1Department of Pediatrics, Massachusetts General Hospital, Boston.

Burns : Journal of the International Society for Burn Injuries
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Note: A simple sample transfer alignment for ultra-high vacuum systems.

The Review of scientific instruments·2016
Same author

Unprecedented staining of polar lipids by a luminescent rhenium complex revealed by FTIR microspectroscopy in adipocytes.

Molecular bioSystems·2016
Same author

Semi-permanent skin staining associated with silver-coated wound dressing Acticoat.

Annals of burns and fire disasters·2015
Same author

The properties of the "ideal" donor site dressing: results of a worldwide online survey.

Annals of burns and fire disasters·2014
Same author

Hair bleaching and skin burning.

Annals of burns and fire disasters·2013
Same author

Effects of oxidation on the nanoscale mechanisms of crack formation in aluminum.

Chemphyschem : a European journal of chemical physics and physical chemistry·2013
Same journal

Integrative multi-omics analysis identifies a mitochondrial dysfunction-associated diagnostic signature, molecular subtypes, and drug repurposing candidates for keloid disease.

Burns : journal of the International Society for Burn Injuries·2026
Same journal

The Teen-Aged Life Impact Burn Recovery Evaluation profile: Item pool development for a computer adaptive test.

Burns : journal of the International Society for Burn Injuries·2026
Same journal

Comments on: "Artificial intelligence for outcome prediction in burn care: A scoping review".

Burns : journal of the International Society for Burn Injuries·2026
Same journal

Artificial intelligence for outcome prediction in burn care: A scoping review.

Burns : journal of the International Society for Burn Injuries·2026
Same journal

Skin grafting and regeneration: Bridging biological barriers towards functional regeneration.

Burns : journal of the International Society for Burn Injuries·2026
Same journal

Experience-based co-design of paediatric burn service guidance to support parent-administered home dressing changes.

Burns : journal of the International Society for Burn Injuries·2026
See all related articles

Platelet activating factor (PAF) alters how the body

Area of Science:

  • Immunology
  • Pharmacology
  • Radiopharmacology

Background:

  • Platelet activating factor (PAF) is a potent inflammatory mediator.
  • The reticuloendothelial system (RES) plays a crucial role in immune surveillance and clearance.
  • Understanding PAF's systemic effects on RES phagocytic activity is important for immune response modulation.

Purpose of the Study:

  • To investigate the in vivo effects of PAF on the phagocytic activity of the rat reticuloendothelial system.
  • To determine if PAF influences the biodistribution and uptake of radiolabeled colloids.
  • To assess the potential of PAF antagonists in mitigating these effects.

Main Methods:

  • Intravenous administration of PAF (2 micrograms) to unanaesthetized rats.
  • In vivo assessment of 99mTc-sulphur colloid (99mTc-SC) uptake in various organs.

Related Experiment Videos

  • Evaluation of intestinal lesion development post-PAF injection.
  • Administration of a PAF antagonist (SRI-64-441) as a pretreatment.
  • In vitro analysis of hydrogen peroxide generation by lung lavage macrophages.

    • Main Results:

    • PAF injection induced intestinal lesions and altered 99mTc-SC uptake.
    • Increased lung uptake and decreased spleen uptake of 99mTc-SC were observed after PAF administration.
    • PAF antagonist pretreatment prevented intestinal lesions and normalized 99mTc-SC uptake.
    • Macrophages from PAF-treated rats showed reduced hydrogen peroxide generation.

    Conclusions:

    • PAF significantly impacts the in vivo phagocytic function of the reticuloendothelial system in rats.
    • PAF administration leads to changes in radiocolloid distribution, suggesting altered RES activity.
    • PAF antagonists hold potential for counteracting PAF-induced immunomodulation and RES dysfunction.