Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nuclear oncogenes.

J Ghysdael1, M Yaniv

  • 1Section de Biologie, Institut Curie, Centre Universitaire, Orsay, France.

Current Opinion in Cell Biology
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

Most nuclear proto-oncogenes are DNA-binding proteins regulating gene expression. Their activity is controlled by external signals and transcription factor interactions, highlighting their role in cellular control mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The calcineurin protein phosphatase is dispensable for BCR-ABL-induced B-ALL maintenance, propagation and response to dasatinib.

Leukemia·2016
Same author

The calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells.

Cell death & disease·2015
Same author

Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemia.

Leukemia·2013
Same author

Leukemia-initiating cell activity requires calcineurin in T-cell acute lymphoblastic leukemia.

Leukemia·2013
Same author

Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia.

Leukemia·2010
Same author

V osteotomy and Ilizarov technique for residual idiopathic or neurogenic clubfeet.

Journal of orthopaedic surgery (Hong Kong)·2008
Same journal

Mechanosensing in immune cells: Implications for migration and beyond.

Current opinion in cell biology·2026
Same journal

Emerging role of organelles in cell migration.

Current opinion in cell biology·2026
Same journal

Nuclear adaptation in cell migration.

Current opinion in cell biology·2026
Same journal

Patterns in motion: Choreographing dynamic cell behaviours during tissue repair.

Current opinion in cell biology·2026
Same journal

Quo vadis reconstituted cell surfaces? Purpose and future perspectives for minimal systems of the cell plasma membrane.

Current opinion in cell biology·2026
Same journal

Nuclear determinants of mRNA and protein isoforms.

Current opinion in cell biology·2026
See all related articles

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Nuclear proto-oncogenes play crucial roles in cellular processes.
  • Recent research suggests a significant function for these genes beyond their traditional roles.

Purpose of the Study:

  • To elucidate the molecular mechanisms of nuclear proto-oncogenes.
  • To understand how proto-oncogenes regulate gene expression and cellular activity.

Main Methods:

  • Analysis of existing scientific literature and accumulated evidence.
  • Focus on the DNA-binding and gene-modulating properties of proto-oncogenes.

Main Results:

  • Most nuclear proto-oncogenes function as sequence-specific DNA-binding proteins.

Related Experiment Videos

  • These proteins are key regulators of gene expression within the cell nucleus.

    • Conclusions:

    • Nuclear proto-oncogenes are critical transcription factors involved in gene regulation.
    • Their synthesis and activity are dynamically controlled by extracellular signals and transcription factor networks.