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Related Concept Videos

Ion Channels01:19

Ion Channels

The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow specific...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...

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Silicon Nanowires and Optical Stimulation for Investigations of Intra- and Intercellular Electrical Coupling
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Nanoengineering ion channels for optical control.

Pau Gorostiza1, Ehud Y Isacoff

  • 1Institut de Bioenginyeria de Catalunya (IBEC), Institució Catalana de Recerca i Estudis Avançats (ICREA), and CIBER-BBN, Parc Científic de Barcelona, Barcelona, Spain.

Physiology (Bethesda, Md.)
|October 18, 2008
PubMed
Summary
This summary is machine-generated.

Chemically modified proteins gain light sensitivity using photoisomerizable tethered ligands. This enables noninvasive control of biological processes with high precision, advancing biological research.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Biophysics

Background:

  • Proteins are fundamental to biological processes.
  • Controlling protein function with external stimuli is a key research goal.
  • Existing methods for protein manipulation often lack precision or invasiveness.

Purpose of the Study:

  • To develop optically actuated proteins for precise biological control.
  • To investigate the use of photoisomerizable tethered ligands for protein modification.
  • To demonstrate noninvasive manipulation of biological processes using light.

Main Methods:

  • Chemical modification of proteins with photoisomerizable tethered ligands.
  • Characterization of the light-sensitive properties of modified proteins.
  • Application of optically actuated proteins to manipulate biological processes in vitro.

Main Results:

  • Successfully endowed proteins with light sensitivity via chemical modification.
  • Demonstrated precise spatiotemporal control over protein function using light.
  • Validated the noninvasive nature of optical actuation in biological systems.

Conclusions:

  • Optically actuated proteins offer a powerful new tool for biological research.
  • Chemical modification with photoisomerizable ligands provides a versatile strategy for protein control.
  • This technology promises to revolutionize the study and manipulation of complex biological systems.