Cardiovascular risk with SCORE system in patients with different degree of renal function impairment

Area of Science:

• Cardiology
• Nephrology
• Public Health

Background:

• The Systematic Coronary Risk Evaluation (SCORE) system is a European-based tool for assessing 10-year fatal cardiovascular event risk.
• Renal impairment is a known risk factor for cardiovascular disease, but its impact on SCORE predictions requires further investigation.

Purpose of the Study:

• To compare cardiovascular risk calculated using the SCORE system in patients with varying degrees of renal impairment.
• To evaluate the accuracy of the SCORE system in high-risk populations, specifically those with chronic kidney disease.

Main Methods:

• Ninety patients were stratified into four groups: no renal failure, predialysis chronic renal failure (CRF), hemodialysis non-diabetic, and hemodialysis diabetic.
• SCORE was calculated based on age, sex, systolic blood pressure, smoking status, and cholesterol levels.
• Statistical analysis was performed to compare SCORE values across the four groups.

Main Results:

• No significant differences in age or blood pressure were observed between the groups.
• Predialysis patients exhibited higher incidences of smokers and elevated cholesterol levels.
• The highest SCORE values were recorded in the predialysis group (5.3+/-4.3), followed by the hemodialysis diabetic (4.06+/-4) and hemodialysis non-diabetic (3.7+/-1.1) groups, compared to the control group (2.5+/-1.8).

Conclusions:

• The SCORE system's traditional risk factors appear insufficient to fully capture cardiovascular risk in patients with chronic kidney disease.
• The SCORE system may underestimate the actual cardiovascular risk in high-risk groups, such as patients with chronic renal disease.
• Further refinement of risk prediction models is needed for populations with renal impairment.