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Updated: Jun 28, 2026
07:45
Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
Published on: February 9, 2021
[The most important factor for active urinary stone formation in patients with urolithiasis]
Sanja Simić-Ogrizović1, Violeta Dopsaj, Svetlana Jovicić
1Institut za urologiju i nefrologiju, Klinicki centar Srbije, Beograd. dst@Eunet.yu
Medicinski Pregled
|October 22, 2008
Summary
Active urinary stone formation is linked to low urine citrate and the presence of urine sediment. Identifying these factors can help prevent recurrent kidney stones.
Area of Science:
- Nephrology
- Urology
- Biochemistry
Context:
- Urolithiasis affects 1-5% of the population, causing significant morbidity.
- Recurrent stone formation presents a challenge due to a deficient understanding of active stone formation risk factors.
Purpose:
- To determine the most important metabolic and clinical parameters for active stone formation.
- To recommend optimal preventive therapies for urolithiasis.
Summary:
- This study evaluated 134 outpatients with urinary stone disease.
- Active stone formers (38.1%) were younger, had higher serum creatinine, lower urine citrate and citrate/calcium ratio, higher urine pH, and more frequent urine sediment (eritrocituria, lenkocituria).
- Multivariate analysis identified low urine citrate and clinically significant urine sediment as key determinants of active stone formation.
Impact:
- Findings highlight the importance of urine citrate levels and urine sediment analysis in managing urolithiasis.
- Suggests potential for targeted preventive strategies focusing on citrate supplementation and infection management.
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