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Updated: Aug 17, 2026

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
[Binding of mitoxantrone and ametantrone with poly(d(G-C)) on the B---Z transition, stimulated by NaCl]
Abstract:
Binding of antitumoral preparations mitoxantrone and ametantrone with right and left helical DNA was investigated. B-Z conformational transition stimulated by NaCl in the molecules of poly[d(G.C)].poly[d(G-C)] in complex with mitoxantrone and ametantrone was studied by the method of circular dichroism. It was shown that these compounds disturb B-Z transition but do not inhibit it.
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