Structure of a 6-pyruvoyltetrahydropterin synthase homolog from Streptomyces coelicolor
James E Spoonamore1, Sue A Roberts, Annie Heroux
1Department of Biochemistry, University of Arizona, Tucson, AZ 85721, USA.
Abstract:
The X-ray crystal structure of the 6-pyruvoyltetrahydropterin synthase (PTPS) homolog from Streptomyces coelicolor, SCO 6650, was solved at 1.5 A resolution. SCO 6650 forms a hexameric T-fold that closely resembles other PTPS proteins. The biological activity of SCO 6650 is unknown, but it lacks both a required active-site zinc metal ion and the essential catalytic triad and does not catalyze the PTPS reaction. However, SCO 6650 maintains active-site residues consistent with binding a pterin-like substrate.
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