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Stress-Induced Changes in Contractile Activity of Rat Aorta and Pulmonary Artery
S V Gusakova1, V S Gusakova2, E A Lebedeva2
1Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia. gusakova.sv@ssmu.ru.
Bulletin of Experimental Biology and Medicine
|September 30, 2026
Abstract:
Immobilization stress (12 and 24 h) simulated in female Wistar rats reduced the amplitude of phenylephrine-induced contraction of isolated aortic and pulmonary artery rings. Acetylcholine-induced, endothelium-dependent vasorelaxation of the aorta and pulmonary artery increased after 12-h stress exposure. Therefore, stress modulates the functional state of these arteries without signs of endothelial injury.
