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Updated: Jun 28, 2026
07:22
Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
Published on: March 11, 2016
Fundus autofluorescence and multiple evanescent white dot syndrome
Claudio Furino1, Francesco Boscia, Nicola Cardascia
1Dipartimento di Oftalmologia ed Otorinolaringoiatria, Università di Bari, Bari, Italy.
Retina (Philadelphia, Pa.)
|October 22, 2008
Summary
Fundus autofluorescence (FAF) precisely identified lesions in multiple evanescent white dot syndrome (MEWDS). This noninvasive imaging aids in diagnosing MEWDS and suggests underlying inflammation affecting retinal cells.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Medical Diagnostics
Background:
- Multiple evanescent white dot syndrome (MEWDS) is an idiopathic inflammatory condition affecting the outer retina.
- Diagnostic challenges exist in identifying MEWDS, particularly the nature of retinal lesions.
Purpose of the Study:
- To characterize fundus autofluorescence (FAF) patterns in patients diagnosed with MEWDS.
- To evaluate the correlation between FAF findings and indocyanine green angiography (ICG) in MEWDS.
Main Methods:
- Retrospective analysis of three patients with MEWDS.
- Utilized indocyanine green angiography (ICG) and fundus autofluorescence (FAF) imaging.
- Compared FAF patterns with ICG findings, focusing on hypocyanescent spots.
Main Results:
- In the acute phase, FAF showed increased autofluorescence corresponding to ICG hypocyanescent spots, though less numerous.
- Visual acuity improved significantly from 20/38 to 20/20 within two months.
- Both FAF and ICG imaging normalized after two months.
Conclusions:
- Fundus autofluorescence (FAF) serves as a valuable noninvasive tool for diagnosing MEWDS.
- FAF findings suggest an inflammatory process impacting the photoreceptor-retinal pigment epithelium complex in MEWDS.
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