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Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
Published on: October 2, 2018
Synthesis, conformational analysis and biological studies of cyclic cationic antimicrobial peptides containing sugar
Tushar Kanti Chakraborty1, Dipankar Koley, Rapolu Ravi
1Indian Institute of Chemical Technology and Centre for Cellular and Molecular Biology, Hyderabad 500607, India. chakraborty@iict.res.in
Abstract:
Sugar amino acid based 24-membered macrocyclic C2-symmetric cationic peptides were designed and synthesized. The cationic group was introduced in the sugar amino acids. The conformation of these cyclic compounds was ascertained through NMR techniques, which proved they were amphipathic in nature. All the compounds were bacteriolytic, showed good activity against the Gr(+ve) and Gr(-ve) bacteria, and exhibited low hemolytic activity.
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