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[Refractory status epilepticus in two children with lethal rhabdomyolysis]

Andreas Kreft1, Niels Rasmussen, Lars Kjaersgård Hansen

  • 1Paediatrisk afdeling, Odense Universitetshospital, DK-5000 Odense. anan.kreft@dadlnet.dk

Ugeskrift for Laeger
|October 23, 2008
PubMed

Insights

Status epilepticus (SE) can lead to lethal rhabdomyolysis, disseminated intravascular coagulation (DIC), and acute renal failure. Prompt treatment is crucial to prevent severe outcomes in patients with SE.

Area of Science:

  • Neurology
  • Critical Care Medicine

Background:

  • Status epilepticus (SE) is a neurological emergency requiring prompt management.
  • Established guidelines exist for antiepileptic drug administration in SE.

Observation:

  • Two cases of SE presented with delayed treatment (1-2 hours) despite adherence to guidelines.
  • Patients required intubation and midazolam infusion for seizure control.

Findings:

  • Both patients developed severe rhabdomyolysis, disseminated intravascular coagulation (DIC), and acute renal failure within 24 hours.
  • Despite intensive care and hemodialysis, both cases were fatal.

Implications:

  • Highlights rare but severe complications of SE, including rhabdomyolysis and organ failure.
  • Suggests individualized treatment plans for patients with recurrent SE may improve outcomes and reduce treatment delays.

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