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Updated: Jul 31, 2026

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Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
Published on: November 8, 2011
Moloney leukemia virus immortalizes B lymphocytes in vitro
J Runnels1, L Serunian, M Thursby
1Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111.
Journal of Virology
|October 1, 1991
Abstract:
An in vitro culture system in which Moloney murine leukemia virus induces immortalization of mature B lymphocytes has been developed. The cell lines derived in this way are nontumorigenic, and virus production is not required to sustain them. This system provides a new in vitro model with which to study the stepwise process of transformation by retroviruses lacking oncogenes.

