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Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Related Experiment Video

Updated: Jun 28, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Highly aggressive lymphomas in adults.

John W Sweetenham1

  • 1Cleveland Clinic Taussig Cancer Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA. sweetej@ccf.org

Hematology/Oncology Clinics of North America
|October 29, 2008
PubMed
Summary
This summary is machine-generated.

Highly aggressive lymphomas, including lymphoblastic and Burkitt types, are uncommon adult non-Hodgkin lymphomas. Intensive chemotherapy offers curative potential, with gene-expression profiling identifying new therapeutic targets.

Related Experiment Videos

Last Updated: Jun 28, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • Highly aggressive lymphomas are rare adult non-Hodgkin lymphomas (NHL), representing 4-5% of cases in Western countries.
  • These aggressive lymphomas primarily include precursor T-cell and B-cell lymphoblastic lymphoma/leukemia and Burkitt's lymphoma/leukemia.

Purpose of the Study:

  • To summarize the characteristics and treatment of highly aggressive lymphomas.
  • To highlight the role of emerging molecular techniques in understanding these diseases.

Main Methods:

  • Review of current literature on highly aggressive lymphomas.
  • Discussion of treatment strategies, including combination chemotherapy.
  • Exploration of gene-expression profiling and its implications.

Main Results:

  • Highly aggressive lymphomas necessitate complex, intensive combination chemotherapy regimens.
  • These intensive treatments hold potential for curative outcomes.
  • Gene-expression profiling is refining the classification of these lymphomas.

Conclusions:

  • Highly aggressive lymphomas require intensive therapeutic approaches.
  • Molecular techniques like gene-expression profiling are crucial for precise diagnosis and identifying novel therapeutic targets.
  • Further research into molecular mechanisms can lead to improved treatment strategies for aggressive lymphomas.