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Published on: November 2, 2016
Determination of mebendazole
1Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.
Talanta
|November 1, 1978
Summary
Accurate and reproducible non-aqueous titrimetric methods were developed for mebendazole determination. Spectrophotometric analysis of mebendazole tablets also proved reliable, indicating potential for automated quality control.
Area of Science:
- Analytical Chemistry
- Pharmaceutical Analysis
Background:
- Accurate quantification of active pharmaceutical ingredients (APIs) is crucial for drug quality and efficacy.
- Mebendazole is an important anthelmintic drug requiring reliable analytical methods for its determination.
Purpose of the Study:
- To present direct and indirect non-aqueous titrimetric methods for mebendazole determination.
- To evaluate a spectrophotometric method for mebendazole quantification in pharmaceutical formulations.
- To assess the reproducibility and automation potential of the developed analytical methods.
Main Methods:
- Non-aqueous titration (direct and indirect) for mebendazole quantification.
- UV-Vis spectrophotometry using perchloric acid as a solvent for tablet analysis.
- Assessment of method reproducibility using relative standard deviation (RSD).
Main Results:
- Non-aqueous titrimetric methods demonstrated high reproducibility with RSD of 0.3%.
- Spectrophotometric determination of mebendazole in 100 mg tablets yielded an RSD of 1.4%.
- The presented analytical methods are suitable for automation in routine quality control.
Conclusions:
- Developed non-aqueous titrimetric and spectrophotometric methods provide accurate and reproducible quantification of mebendazole.
- These methods are practical for routine pharmaceutical analysis and quality control.
- The ease of automation suggests efficient implementation in laboratory settings.
