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Sensitive sequential injection determination of naproxen based on interaction with beta-cyclodextrin.

Eftychia-Pavlina Zisiou1, Paula C A G Pinto, M Lúcia M F S Saraiva

  • 1REQUIMTE/Serviço de Química-Física, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, 4099-030 Porto, Portugal.

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|October 31, 2008
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Summary
This summary is machine-generated.

A new sequential injection analysis (SIA) method enhances fluorimetric detection of naproxen using beta-cyclodextrin complexation. This precise and sensitive automated technique accurately quantifies naproxen in pharmaceutical formulations.

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Area of Science:

  • Analytical Chemistry
  • Pharmaceutical Analysis

Background:

  • Naproxen is a widely used nonsteroidal anti-inflammatory drug (NSAID).
  • Accurate quantification of naproxen in pharmaceutical formulations is crucial for quality control.

Purpose of the Study:

  • To develop a sensitive and automated sequential injection analysis (SIA) method for naproxen determination.
  • To utilize the complexation of naproxen with beta-cyclodextrin (beta-CD) to enhance fluorimetric detection.

Main Methods:

  • Sequential injection analysis (SIA) system for automated sample handling and analysis.
  • Fluorimetric detection with excitation at 280 nm and emission at 356 nm.
  • Complexation of naproxen with beta-cyclodextrin to amplify the fluorescence signal.

Main Results:

  • Linear calibration plots were achieved for naproxen concentrations up to 1x10(-5) mol/L.
  • The method demonstrated good precision (R.S.D. < 2.1%) and a low detection limit (1.9x10(-7) mol/L).
  • A sampling rate of approximately 70 samples per hour was achieved.

Conclusions:

  • The developed SIA methodology provides a sensitive, precise, and automated approach for naproxen determination.
  • The method is suitable for the analysis of naproxen in pharmaceutical formulations with minimal interference from excipients.
  • The results obtained by the SIA method showed good agreement with the reference procedure (< 3.6% relative deviation).