Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Distribution of histamine in developing rat tissues.

M J Nissinen¹, P Panula

¹Department of Anatomy, University of Helsinki, Finland.

Agents and Actions

|May 1, 1991

Summary

Histamine appears widely in fetal rat organs starting on embryonic day 10, particularly in the liver. This amine is present in various cell types across multiple organs by late fetal development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Knockout of histamine receptor H3 alters adaptation to sudden darkness and monoamine levels in the zebrafish.

Acta physiologica (Oxford, England)·2017

Same author

Narcolepsy patients' blood-based miRNA expression profiling: miRNA expression differences with Pandemrix vaccination.

Acta neurologica Scandinavica·2017

Same author

Interactions of the orexin/hypocretin neurones and the histaminergic system.

Acta physiologica (Oxford, England)·2014

Same author

The tyrosine hydroxylase 2 (TH2) system in zebrafish brain and stress activation of hypothalamic cells.

Histochemistry and cell biology·2014

Same author

Expression of histamine receptor genes Hrh3 and Hrh4 in rat brain endothelial cells.

British journal of pharmacology·2013

Same author

Histamine is required for H₃ receptor-mediated alcohol reward inhibition, but not for alcohol consumption or stimulation.

British journal of pharmacology·2013

Area of Science:

Developmental biology
Neuroscience
Immunology

Background:

Histamine is a biogenic amine with diverse physiological roles.
Its presence and function during embryonic development are not fully understood.

Purpose of the Study:

To investigate the spatiotemporal distribution of histamine during rat fetal and early postnatal development.
To identify specific organs and cell types expressing histamine during these critical developmental stages.

Main Methods:

Utilized an antiserum against conjugated histamine for immunofluorescence.
Employed standard indirect immunofluorescence techniques on fixed tissues.
Examined tissues from embryonic day 10 (E10) through early postnatal stages.

Main Results:

Histamine-immunoreactivity (HA-ir) was first detected in the embryonic liver on E10.
By E16, HA-ir was observed in the stomach wall, kidneys, and fetal heart.
Extensive HA-ir distribution was noted in organs like lungs, gastric mucosa, heart muscle, and skin by E20.

Conclusions:

Histamine is widely distributed in various cell types during rat fetal development.
The early appearance and broad distribution suggest a significant role for histamine in organogenesis.
Further research is warranted to elucidate the specific functions of histamine during development.

Related Experiment Videos