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Published on: August 13, 2019
Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-2: histologic
Ulf M E Wikesjö1, Mohammed Qahash, Giuseppe Polimeni
1Laboratory for Applied Periodontal and Craniofacial Regeneration, Medical College of Georgia, School of Dentistry, Augusta, GA 30912, USA. uwikesjo@mcg.edu
Journal of Clinical Periodontology
|November 4, 2008
Summary
Recombinant human BMP-2 (rhBMP-2) on titanium implants promotes bone growth and osseointegration. However, higher rhBMP-2 concentrations can lead to adverse effects like implant displacement.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Orthopedic Research
Background:
- Bone morphogenetic proteins (BMPs) on titanium surfaces stimulate bone formation in various animal models.
- Recombinant human BMP-2 (rhBMP-2) is investigated for its osteoinductive potential.
Purpose of the Study:
- To evaluate rhBMP-2 coated porous oxide titanium implants for stimulating local bone formation.
- To assess osseointegration and vertical alveolar ridge augmentation using rhBMP-2.
Main Methods:
- Canine model with bilateral supra-alveolar peri-implant defects.
- Implants coated with varying concentrations of rhBMP-2 (0.75, 1.5, 3.0 mg/ml) or uncoated controls.
- Histologic evaluation with bone markers at 8 weeks post-surgery.
Main Results:
- rhBMP-2 coated implants showed significant bone formation and osseointegration.
- Optimal bone formation and Type II bone characteristics observed at 0.75 and 1.5 mg/ml rhBMP-2.
- Higher concentration (3.0 mg/ml) resulted in immature bone, seroma, and implant displacement.
Conclusions:
- rhBMP-2 on titanium implants effectively induces bone formation and osseointegration.
- Clinically relevant vertical alveolar ridge augmentation was achieved.
- Higher rhBMP-2 doses are associated with undesirable side effects.
