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Updated: Jun 28, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
Published on: June 4, 2012
[Pigs as an infection source for methicillin resistant Staphylococcus aureus infections in humans]
Christina H Ruhlmann1, Hans Jørn J Kolmos, Jette E Kristiansen
1Onkologisk Afdeling R, Odense Universitetshospital, DK-5000 Odense C. ruhlmann@dadlnet.dk
Abstract:
Recent Dutch studies indicate that methicillin-resistant Staphylococcus aureus (MRSA) sequence type 398 is widely distributed in pigs and may give rise to infection in humans. In this study we present the first two Danish cases of MRSA infection, which in all probability were acquired from occupational contact with pigs. One infection presented as a severe surgical wound infection, following knee surgery, the other as a superficial ear lobe infection. Both MRSA strains were multiresistant, sequence type 398, Spa-type t034, and Panton-Valentine leukocidin-encoding gene negative.
Insights
Methicillin-resistant Staphylococcus aureus (MRSA) sequence type 398, common in pigs, caused two Danish infections through occupational contact. Both cases involved multiresistant MRSA strains, highlighting potential human health risks from livestock.
Area of Science:
- Veterinary Medicine
- Infectious Diseases
- Public Health
Background:
- Methicillin-resistant Staphylococcus aureus (MRSA) sequence type 398 is increasingly prevalent in swine populations.
- Studies suggest a potential for zoonotic transmission of MRSA ST398 from pigs to humans.
- Understanding transmission routes and clinical presentations is crucial for public health surveillance.
Observation:
- Two distinct cases of MRSA ST398 infection in Denmark are reported.
- Infections were likely acquired through occupational contact with pigs.
- Clinical presentations included a severe surgical wound infection and a superficial ear lobe infection.
Findings:
- Both Danish MRSA isolates belonged to sequence type 398 and Spa-type t034.
- The MRSA strains were multiresistant, indicating limited treatment options.
- Neither isolate carried the Panton-Valentine leukocidin-encoding gene.
Implications:
- These cases represent the first documented MRSA ST398 infections in Denmark linked to pig contact.
- Highlights the occupational health risks for individuals working with livestock.
- Underscores the need for continued monitoring of MRSA ST398 in animal and human populations.
Related Concept Videos
Clinical Significance of Antibiotic Resistance
Mechanism of Antibiotic Resistance in MRSA
Staphylococcal Skin Infections

