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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

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Updated: Jun 28, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Engineered polymers for advanced drug delivery.

Sungwon Kim1, Jong-Ho Kim, Oju Jeon

  • 1Department of Pharmaceutics and Biomedical Engineering, Purdue University, West Lafayette, IN 47907-2032, USA.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|November 4, 2008
PubMed
Summary
This summary is machine-generated.

Engineered polymers enable advanced drug delivery systems and smart materials that respond to environmental cues. These polymers are crucial for drug targeting, molecular imaging, and nanotechnology applications.

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Area of Science:

  • Polymer Science
  • Materials Science
  • Biotechnology

Background:

  • Engineered polymers are foundational to advanced drug delivery systems.
  • Advances in polymer chemistry have led to smart polymers responsive to environmental stimuli like temperature, pH, and biomolecules.
  • Polymer responses include swelling, deswelling, and degradation.

Purpose of the Study:

  • To review the utilization of engineered polymers in traditional drug delivery.
  • To examine emerging applications of engineered polymers in nanotechnology.
  • To highlight the role of polymers in drug targeting and molecular imaging.

Main Methods:

  • Literature review of engineered polymers in drug delivery.
  • Analysis of smart polymer characteristics and responses.
  • Exploration of polymer applications in nanotechnology and molecular imaging.

Main Results:

  • Engineered polymers facilitate targeted drug delivery via conjugates and nano/micro-particles.
  • Smart polymers offer tunable responses to specific environmental triggers.
  • Polymeric systems are increasingly used in molecular imaging and nanotechnology.

Conclusions:

  • Engineered polymers are versatile materials for sophisticated drug delivery systems.
  • Smart polymers represent a significant advancement, enabling responsive and targeted therapeutic strategies.
  • The integration of engineered polymers into nanotechnology opens new frontiers in biomedical applications.