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Updated: Jun 28, 2026

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
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Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source

Published on: May 29, 2021

Direct optical detection in fragment-based screening.

Florian Pröll1, Peter Fechner, Günther Proll

  • 1Institute of Physical and Theoretical Chemistry, Eberhard Karls University of Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany. florian.proell@ipc.uni-tuebingen.de

Analytical and Bioanalytical Chemistry
|November 4, 2008
PubMed
Summary
This summary is machine-generated.

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Label-free biosensors offer valuable, label-free drug design insights. These optical biosensors are versatile tools for fragment-based screening and future drug development.

Area of Science:

  • Biotechnology
  • Analytical Chemistry
  • Drug Discovery

Background:

  • Label-free biosensors utilizing direct optical detection are prevalent in research.
  • Increasing automation and throughput enhance their utility for pharmaceutical applications.

Purpose of the Study:

  • To highlight the advantages of direct optical biosensors in drug design.
  • To emphasize their role in fragment-based drug design and screening.

Main Methods:

  • Focus on direct optical detection principles.
  • Integration with complementary techniques like NMR, mass spectrometry, and X-ray crystallography.

Main Results:

  • Label-free biosensors provide crucial information for drug design.

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Last Updated: Jun 28, 2026

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
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Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source

Published on: May 29, 2021

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
06:26

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Published on: May 16, 2021

Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin
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Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin

Published on: March 3, 2021

  • Optical biosensors are effective for fragment-based screening.

    • Conclusions:

    • Direct optical biosensors are valuable tools in pharmaceutical research.
    • They are particularly advantageous for fragment-based drug design and screening processes.