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Updated: Jun 28, 2026
07:07
Endoscopy Guided Photoablation of Endometrial Cysts using a 980 nm Laser with a Contact Fiber in Mares
Published on: July 16, 2020
Uterine involution and endometrial function in postpartum pony mares.
Susanne Jischa1, Ingrid Walter, Norbert Nowotny
1Centre for Artificial Insemination and Embryo Transfer, University of Veterinary Sciences, 1210 Vienna, Austria.
American Journal of Veterinary Research
|November 5, 2008
Summary
Postpartum mare endometrial regeneration involves initial cell death followed by proliferation, with changing lectin binding and increased hormone receptor expression preparing the uterus for pregnancy.
Area of Science:
- Veterinary Science
- Reproductive Biology
- Histology
Background:
- Postpartum uterine involution is crucial for subsequent fertility in mares.
- Understanding endometrial regeneration mechanisms is key to improving reproductive outcomes.
Purpose of the Study:
- To investigate endometrial regeneration in postpartum mares.
- Analyze histologic features, cell apoptosis and proliferation markers, lectin binding, cytokines, and hormone receptors.
Main Methods:
- Examined 9 postpartum mares on days 1, 9, and 16.
- Performed histologic examination, immunohistochemistry (Ki-67, caspase 3), and quantitative real-time PCR for gene expression.
Main Results:
- Neutrophils initially predominated, replaced by lymphocytes/macrophages by day 9.
- Apoptosis markers (caspase 3) decreased, while proliferation markers (Ki-67) increased from day 1 to 9.
- Estrogen and progesterone receptor expression increased significantly by day 9.
Conclusions:
- Postpartum endometrial regeneration is characterized by initial apoptosis followed by cell proliferation.
- Changes in lectin binding reflect alterations in the endometrial glycocalyx.
- Upregulation of estrogen and progesterone receptors enables the endometrium to respond to hormonal cues for potential pregnancy.
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