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Updated: Jun 28, 2026
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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
Performance of glaucoma progression analysis software in a glaucoma population
Francisco Arnalich-Montiel1, Pilar Casas-Llera, Francisco J Muñoz-Negrete
1Glaucoma Unit, Ramón y Cajal University Hospital, Carretera Colmenar Viejo km 9, 1, Madrid, 28034, Spain. farnalich@gmail.com
Summary
Glaucoma Progression Analysis (GPA) strongly correlates with clinical criteria for detecting visual field loss in glaucoma patients. This analysis aids clinicians in identifying disease progression with high accuracy.
Area of Science:
- Ophthalmology
- Optometry
- Clinical Research
Background:
- Glaucoma is a leading cause of irreversible blindness.
- Accurate detection of visual field progression is crucial for managing glaucoma.
- Current methods for assessing visual field progression vary.
Purpose of the Study:
- To compare visual field progression detection between Glaucoma Progression Analysis (GPA) and objective clinical criteria.
- To evaluate the diagnostic performance of GPA in identifying glaucomatous visual field damage.
Main Methods:
- Retrospective study of 93 glaucoma patients with at least five visual fields.
- Visual field progression analyzed by a masked observer using GPA and clinical criteria.
- Agreement quantified by kappa analysis; GPA performance assessed using clinical criteria as reference.
Main Results:
- Prevalence of progressive visual field damage was similar: 30% (GPA) vs. 29% (clinical criteria).
- High agreement between GPA and clinical criteria (kappa=0.87) when requiring two consecutive fields for progression.
- GPA demonstrated high sensitivity (93%) and specificity (95%) with a positive likelihood ratio of 20.
Conclusions:
- GPA shows a strong correlation with objective clinical assessment of visual fields in glaucoma.
- GPA is a valuable tool for clinicians to detect glaucomatous progression.
- GPA offers high specificity, a strong positive likelihood ratio, and good sensitivity.
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