Related Experiment Video
Updated: Jun 28, 2026
09:42
A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
Published on: June 4, 2021
Immunochemical composition of cryoglobulins generated in stroke
Levon Manukyan1, Anna Boyajyan, Arsen Arakelyan
1Institute of Molecular Biology, National Academy of Sciences of Armenia, 7 Hasratyan St., Yerevan 0014, Armenia.
Journal of Clinical Immunology
|November 5, 2008
Summary
Elevated cryoglobulin levels, containing immunoglobulins and lipoproteins, were found in ischemic stroke patients. These cryoglobulins may drive post-stroke inflammation by activating complement and cytokines.
Area of Science:
- Immunology
- Neurology
- Pathophysiology
Background:
- Cryoglobulins are immune complexes composed of immunoglobulins.
- They can bind C-reactive protein, lipoproteins, activate complement, and stimulate TNF-alpha.
- This suggests a role in ischemic stroke pathology.
Purpose of the Study:
- To investigate cryoglobulin levels in ischemic stroke patients.
- To determine the composition of cryoglobulins during stroke onset.
Main Methods:
- Blood cryoglobulin levels were measured at various time points post-stroke.
- Cryoglobulins were isolated and their composition analyzed on day 1.
Main Results:
- Significantly elevated cryoglobulin levels were observed from days 1-14.
- Peak cryoglobulin levels occurred on day 3 post-stroke.
Conclusions:
- Cryoglobulins comprised polyclonal IgG, IgA, IgM, C3, C1q, and lipoproteins (lipoprotein-X, beta-lipoprotein).
- Cryoglobulins likely contribute to post-ischemic inflammation via complement activation and cytokine production.
