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Automated Microbial Diagnostics01:24

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Decision support systems for antibiotic prescribing.

Vitali Sintchenko1, Enrico Coiera, Gwendolyn L Gilbert

  • 1Centre for Infectious Diseases and Microbiology, Level 3, ICPMR,Westmead Hospital, Westmead, NSW 2141, Australia. vitali.sintchenko@swahs.health.nsw.gov.au

Current Opinion in Infectious Diseases
|November 7, 2008
PubMed
Summary
This summary is machine-generated.

Computerized antibiotic prescribing guidelines and decision support systems enhance clinical performance and patient outcomes. However, the safety of these electronic systems requires further investigation, especially with rising antimicrobial resistance.

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Last Updated: Jun 28, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

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Published on: August 30, 2018

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
09:59

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Published on: July 21, 2023

Area of Science:

  • Medical Informatics
  • Clinical Pharmacy
  • Infectious Diseases

Background:

  • Antibiotic prescribing is critical for patient outcomes and combating antimicrobial resistance.
  • Computerized decision support systems (CDSS) offer potential to optimize antibiotic use.

Purpose of the Study:

  • To review recent advancements in computerized evidence-based guidelines and CDSS for antibiotic prescribing.
  • To assess their impact on prescribing effectiveness and efficiency.

Main Methods:

  • Systematic review of literature on electronic guidelines and decision support systems.
  • Analysis of studies reporting clinical performance and patient outcomes.
  • Evaluation of safety concerns and future directions in antibiotic prescribing support.

Main Results:

  • Electronic guidelines and protocols are common, particularly for empirical antibiotic selection.
  • Most CDSS improve clinical performance and, in many cases, patient outcomes.
  • Safety of electronic prescribing systems in practice is a growing concern.
  • Bioinformatics can aid complex antimicrobial prescribing in multidrug-resistant infections.

Conclusions:

  • Renewed interest in prescribing decision support shifts focus from diagnosis to patient management.
  • Current systems are evolving from broad diagnostic support to condition-specific aids.
  • Task-specific decision aids are emerging for targeted clinical challenges.