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Updated: Jun 28, 2026
09:31
In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
Pathologic features of renal cortical tumors
Satish K Tickoo1, Anuradha Gopalan
1Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA. tickoos@mskcc.org
The Urologic Clinics of North America
|November 11, 2008
Summary
A better understanding of renal tumors refines classification. Features like "granular cell" and "sarcomatoid" are nonspecific, and molecular insights will advance targeted kidney cancer therapies.
Area of Science:
- Nephrology
- Oncology
- Pathology
Background:
- The morphologic spectrum of renal cortical tumors is evolving.
- Previous classifications relied on nonspecific descriptors.
- Advances in understanding tumor heterogeneity are crucial.
Purpose of the Study:
- To highlight the clinical relevance of updated renal tumor classification.
- To emphasize the limitations of nonspecific morphologic descriptors.
- To underscore the future role of molecular insights in kidney cancer therapy.
Main Methods:
- Review of current literature on renal cortical tumor morphology.
- Analysis of the clinical significance of tumor descriptors.
- Discussion of emerging molecular targets in kidney cancer.
Main Results:
- Recognition that "granular cell" and "sarcomatoid" are not distinct tumor types but nonspecific features.
- Identification of a variety of renal tumor types exhibiting these features.
- Acknowledgement of the importance of molecular-driven antigen expression.
Conclusions:
- Updated classification of renal cortical tumors improves clinical relevance.
- Nonspecific descriptors like "granular cell" and "sarcomatoid" require reevaluation.
- Molecular-driven antigen expression is key for future targeted kidney cancer therapies.
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