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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...

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Related Experiment Video

Updated: Jun 28, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Noncoding RNAs in Long-Term Memory Formation.

Tim R Mercer1, Marcel E Dinger, Jean Mariani

  • 1Institute for Molecular Biosciences, University of Queensland, Brisbane, Australia.

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
|November 11, 2008
PubMed
Summary
This summary is machine-generated.

Non-protein-coding RNAs (ncRNAs) are crucial for memory formation and maintenance. This review highlights their roles in regulating gene expression and neuronal communication, suggesting new research avenues.

Related Experiment Videos

Last Updated: Jun 28, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genomics

Background:

  • Current memory research primarily focuses on proteins.
  • Genomic studies reveal abundant non-protein-coding RNA (ncRNA) transcription.
  • ncRNAs are vital for nervous system complexity and mammalian brain function.

Purpose of the Study:

  • To review the critical role of ncRNAs in memory formation and maintenance.
  • To explore ncRNA involvement in synaptic activity, gene regulation, and neuronal communication.
  • To propose novel research directions in ncRNA-mediated memory mechanisms.

Main Methods:

  • Literature review applying recent advances in ncRNA biology.
  • Analysis of ncRNA roles in mRNA regulation (translation, stability, editing).
  • Examination of ncRNAs in epigenetic and transcriptional programs for memory storage.
  • Consideration of ncRNAs in intercellular neuronal communication.

Main Results:

  • ncRNAs regulate mRNA populations in response to synaptic activity during memory formation.
  • ncRNAs are involved in epigenetic and transcriptional programs underlying long-term memory storage.
  • ncRNAs can be trafficked between neurons, suggesting a role in inter-neuronal communication.

Conclusions:

  • Emerging evidence points to a central role for ncRNAs in memory formation and maintenance.
  • ncRNAs represent a significant, understudied component of memory's molecular basis.
  • Further research into ncRNA functions can uncover novel therapeutic targets for cognitive disorders.