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Updated: Jun 28, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Tandem conjugate addition-elimination reaction promoted by chiral pyrrolidinyl sulfonamide (CPS)
Junye Xu1, Xiao Fu, Ruijuan Low
1Department of Chemistry, National University of Singapore, Singapore.
Abstract:
Chiral pyrrolidinyl sulfonamides have been found to promote the conjugate addition-elimination reaction between activated allylic bromides and 1,3-dicarbonyl compounds with high enantioselectivities and the highly functionalised products can be used to generate a variety of interesting enantiomerically pure compounds via simple transformations.
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