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Updated: Jun 28, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Developing multilevel search filters for clinical questions represented as conceptual graphs
Evandro E S Ruiz1, Marina Chilov, Stephen B Johnson
1Department of Biomedical Informatics, Columbia University, New York, NY, USA.
This study introduces a search strategy model for precise clinical document retrieval. The model efficiently finds relevant articles early in the search process, saving time and resources.
Area of Science:
- Information Science
- Medical Informatics
Background:
- Effective retrieval of clinical documents is crucial for evidence-based practice.
- Existing search methods may lack precision, leading to information overload.
Purpose of the Study:
- To develop and implement a search strategy model for high-precision document retrieval in response to clinical queries.
- To optimize the process of finding relevant medical literature.
Main Methods:
- Designed a staged configuration of search filters.
- Implemented a model that retrieves documents from most precise to least specific.
- Tested the model's effectiveness in a simulated clinical query environment.
Main Results:
- The search strategy model successfully retrieved relevant documents with high precision.
- Most pertinent articles were identified at the initial stages of the search process.
- The staged filtering approach proved effective for various clinical queries.
Conclusions:
- The proposed search strategy model enhances the efficiency and precision of clinical document retrieval.
- Early-stage retrieval of relevant articles is achievable with the implemented model.
- This approach can significantly aid healthcare professionals in accessing timely and accurate information.
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