Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Glial Cells01:04

Glial Cells

Overview
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cellular heterogeneity and therapeutic response profiling of human IDH + glioma stem cell cultures.

Scientific reports·2025
Same author

Switching high efficacy therapies in Multiple Sclerosis: Does real world experience support such a strategy?

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2025
Same author

Effect of diroximel fumarate on gut dysbiosis and autoimmunity in the central nervous system.

International immunopharmacology·2025
Same author

Importance of radiation-related cognitive decline in older adults who receive cranial radiation.

Expert review of anticancer therapy·2025
Same author

Cellular heterogeneity and therapeutic response profiling of human IDH+ glioma stem cell cultures.

bioRxiv : the preprint server for biology·2025
Same author

The mechanism of disease progression by aging and age-related gut dysbiosis in multiple sclerosis.

Neurobiology of disease·2025
Same journal

Protein acetylation modification in tissue fibrosis: Opportunities and challenges.

Pharmacology & therapeutics·2026
Same journal

Nipocalimab and other FcRn blockers in neuromuscular disorders.

Pharmacology & therapeutics·2026
Same journal

C26:0-lysophosphatidylcholine in X-linked adrenoleukodystrophy.

Pharmacology & therapeutics·2026
Same journal

The CircRNA/miRNA axis in breast cancer: From molecular mechanisms to clinical translation.

Pharmacology & therapeutics·2026
Same journal

Glymphatic-meningeal lymphatic dysfunction in epilepsy: novel mechanistic insights and therapeutic avenues.

Pharmacology & therapeutics·2026
Same journal

The neurovascular unit under siege: Molecular mechanisms and potential drug target for cerebral edema.

Pharmacology & therapeutics·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Protective autoimmunity in the nervous system.

Jerome J Graber1, Suhayl Dhib-Jalbut

  • 1New York University School of Medicine, Department of Neurology, New York, NY, USA.

Pharmacology & Therapeutics
|November 13, 2008
PubMed
Summary
This summary is machine-generated.

The immune system plays a dual role in the nervous system, offering protection and aiding repair in various neurological conditions. Research highlights its beneficial functions and potential as a therapeutic target for brain diseases.

More Related Videos

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
09:29

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis
05:55

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis

Published on: December 1, 2023

Related Experiment Videos

Last Updated: Jun 28, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
09:29

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis
05:55

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis

Published on: December 1, 2023

Area of Science:

  • Neuroimmunology
  • Neuroscience
  • Cellular Biology

Background:

  • The immune system exhibits both damaging and protective effects within the nervous system.
  • Various immune cells and molecules are involved in neural injury and repair processes.

Purpose of the Study:

  • To explore the beneficial roles of the immune system in the central and peripheral nervous system.
  • To investigate the potential of immune system modulation as a therapeutic strategy for neurological disorders.

Main Methods:

  • Review of existing literature on immune system involvement in neurological diseases.
  • Analysis of immune cell interactions with neural cells and stem cells.
  • Examination of current and experimental therapies targeting immune pathways.

Main Results:

  • Immune cells produce neurotrophic factors, support neural progenitor stem cell proliferation, and enhance neuroprotection.
  • Protective immune functions are evident in conditions like stroke, multiple sclerosis, and neurodegenerative diseases.
  • Existing therapies (e.g., glatiramer acetate, interferon-beta) and experimental interventions show promise in leveraging these beneficial aspects.

Conclusions:

  • The immune system possesses significant protective and reparative capabilities within the nervous system.
  • Targeting the beneficial functions of the immune system represents a promising therapeutic avenue for neurological diseases.