Related Experiment Video

Updated: Jun 28, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Different effect of exercise on left ventricular diastolic time and interventricular dyssynchrony in heart failure

Gunnar Plehn1, Julia Vormbrock, Thomas Butz

  • 1Department of Cardiology and Angiology, Marienhospital Herne, University of Bochum, Germany. gunnar.plehn@ruhr-unibochum.de

International Journal of Medical Sciences
|November 13, 2008
PubMed

Insights

Exercise significantly shortens left ventricular (LV) diastolic time in heart failure patients, especially those with left bundle branch block (LBBB). This diastolic dysfunction is linked to mechanical dyssynchrony.

Area of Science:

  • Cardiology
  • Heart Failure Research
  • Cardiac Electrophysiology

Background:

  • Idiopathic dilated cardiomyopathy (IDCM) is characterized by prolonged left ventricular (LV) systole and reduced diastolic time.
  • Previous studies indicated altered diastolic time in IDCM patients.

Purpose of the Study:

  • To investigate the impact of exercise on heart rate-corrected diastolic time.
  • To compare diastolic time changes in healthy controls, IDCM patients (with and without LBBB), and patients with isolated LBBB.

Main Methods:

  • Combined hemodynamic-radionuclide angiography during exercise.
  • High temporal resolution analysis of ventricular time-activity curves.
  • Quantification of loss of diastolic time (LDT) using regression analysis.

Main Results:

  • Significant LDT observed at rest and during exercise in IDCM patients with LBBB.
  • Elevated LDT during peak exercise in IDCM patients with normal activation, associated with increased interventricular mechanical dyssynchrony.
  • LDT in isolated LBBB patients was not detailed in the abstract.

Conclusions:

  • Abnormal shortening of LV diastolic time during exercise is common in heart failure.
  • Mechanical dyssynchrony is a key factor contributing to diastolic dysfunction in these patients.
Abstract

Keywords:
diastolic timeexercise testheart failureinterventricular dyssynchronyleft bundle branch block

More Related Videos

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Related Concept Videos

Heart Failure Drugs: β-Blockers01:22

Heart Failure Drugs: β-Blockers

β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation, vasodilation, and...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...