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Updated: Jun 28, 2026
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Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
Published on: November 9, 2016
Botulinum toxin A injection for primary and recurrent chalazia
Tamara Knezevic1, Renata Ivekovic, Jasna Pavicic Astalos
1University Department of Ophthalmology, University Hospital Sestre milordnice, Zagreb, Croatia.
Summary
Subcutaneous botulinum toxin A injections effectively treat chalazia. This study found the treatment safe and successful for both primary and recurrent cases, with significant lesion regression observed.
Area of Science:
- Ophthalmology
- Dermatology
Background:
- Chalazia are common eyelid lesions.
- Primary and recurrent chalazia pose treatment challenges.
Purpose of the Study:
- To evaluate the efficacy and safety of subcutaneous botulinum toxin A injections for chalazia.
- To compare botulinum toxin A treatment with placebo.
Main Methods:
- Prospective, placebo-controlled trial involving 63 patients.
- Patients received either botulinum toxin A injections or placebo.
- Outcomes included lesion size, clinical resolution, time to resolution, and complications.
Main Results:
- Botulinum toxin A showed statistically significant therapeutic success and lesion regression compared to placebo.
- No significant difference in complication rates between groups was observed.
Conclusions:
- Subcutaneous botulinum toxin A is an effective and safe treatment for primary and recurrent chalazia.
- Cases unresponsive to multiple injections may require surgical excision or antibiotics.
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