Related Experiment Video
Updated: Jun 28, 2026
11:31
High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
Published on: August 16, 2019
Translating molecular insights in autoimmunity into effective therapy
1Kennedy Institute of Rheumatology Division, Imperial College London, London W6 8LH, UK. m.feldmann@imperial.ac.uk
Annual Review of Immunology
|November 15, 2008
Summary
Research into autoimmunity and rheumatoid arthritis (RA) revealed that tumor necrosis factor (TNF) drives RA pathogenesis. Targeting TNF with monoclonal antibodies revolutionized RA treatment, highlighting cytokines as key therapeutic targets.
Area of Science:
- Immunology
- Rheumatology
- Pathogenesis of Autoimmune Diseases
Background:
- Early research focused on autoimmunity and immune regulation.
- Investigation linked upregulated antigen presentation to human autoimmunity.
- Explored the role of cytokines in rheumatoid arthritis (RA) pathogenesis.
Discussion:
- Defined a TNF-dependent cytokine cascade driving RA manifestations.
- Demonstrated the therapeutic potential of targeting cytokines in RA.
- Successful clinical trials of anti-TNF monoclonal antibodies in RA patients.
Key Insights:
- Cytokines are critical rate-limiting steps in disease pathogenesis.
- Cytokine blockade represents a viable therapeutic strategy.
- Targeting TNF revolutionized RA treatment and medical practice.
Outlook:
- Exploring the hypothesis that cytokine blockade can address diverse major medical needs.
- Investigating the broader applicability of cytokine-targeting therapies.
- Continuing research into novel therapeutic targets in autoimmune diseases.
Related Concept Videos
01:29Autoimmune Disorders
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Concept and Mechanism of Autoimmune Diseases
The immune system...
01:29Pharmacogenomics: Identification of New Drug Targets
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.