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Updated: Jun 27, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
[Tooth loss in diabetic patients with and without chronic kidney disease and dialysis]
E de la Rosa1, S Cruz, A Mondragón
1Departamento de Atención a la Salud, Universidad Autónoma Metropolitana-Xochimilco, Hospital General de Zona N. 50, Instituto Mexicano del Seguro Social, San Luis Potosí, SLP, México. delarosa0712@msn.com
Aim:
To compare tooth loss (TL) in ESRD (ESRD DM) and non-ESRD (DM) type 2 diabetic patients.
Methods:
Teeth loss was quantified, and dentition classified as: Non-Compromised (NCD) with > or = 25 teeth, partially compromised (PCD) with 9 to 24, and compromised (CD) with 0 to 8 teeth.
Results:
ESRD DM and DM: n> or = 103 and 130, mean age 57.9 and 58.5 yr (p> or =0.716), and at diabetes diagnosis 38.5 and 47.8 yr (p<0.001). Edentulous 23.5% and 13.8% (p> or =0.057), NCD 24.5% and 35.4% (p> or =0.074). TL was strongly associated mainly to periodontal disease (p<0.001). For ESRD DM, a low serum albumin (<3.5 g/dl) was more prevalent in peritoneal dialysis cases (p> or =0.0014), women (p> or =0.0100), people reporting unpleasant taste (UT) (p> or =0.0174), and those with a CD (p> or =0.0242).
Conclusions:
There was a clear trend for more severe TL in ESRD DM cases, but no statistical difference was found. The association between low serum albumin, UT and CD imply a need for treatment of these conditions as a part of nutritional intervention in ESRD DM cases.
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