Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Stages of General Anesthesia01:22

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring social determinants of learning in nursing education: Barriers, opportunities, and strategies using the Chamberlain SDOL Framework.

Journal of professional nursing : official journal of the American Association of Colleges of Nursing·2026
Same author

Impact of Ankylosing Spondylitis/Diffuse Idiopathic Skeletal Hyperostosis on Postoperative and Patient-Reported Outcomes Following Elective Cervical and Lumbar Surgery.

Global spine journal·2026
Same author

A Comparison of Demographic and Microorganism Differences Between De Novo and Postoperative Infections.

Clinical spine surgery·2026
Same author

Evaluating the Impact of Chronic Beta Blocker Use on Postoperative Opioid Consumption Following Lumbar Fusion: A Propensity Matched Analysis.

Clinical spine surgery·2026
Same author

The Impact of Intraoperative Intravenous Dexamethasone on Postoperative Outcomes in Patients with Diabetes Undergoing Posterior Cervical Decompression and Fusion.

Clinical spine surgery·2026
Same author

Causes of Fever in a Cohort of Nepali Children and the Potential Impact of Molecular Testing During a Dengue Fever Outbreak.

The Pediatric infectious disease journal·2026
Same journal

Gut Microbiome Associations With Depressive Symptoms in Women With Gynecologic Cancer: A Longitudinal Study.

Biological research for nursing·2026
Same journal

Impact of Different Exercise Modalities on Visceral Adipose Tissue in Normal Weight and Low-Overweight Individuals: A Systematic Review and Meta-Analysis.

Biological research for nursing·2026
Same journal

Temporal Relationships Between Systemic Inflammatory Markers and Urinary I-FABP in Preterm Infants: Evidence that Intestinal Inflammation Precedes Systemic Inflammation.

Biological research for nursing·2026
Same journal

Postpartum Urinary Retention in Vaginal Delivery Women Under Epidural Analgesia: Risk Factors and Nursing Strategies.

Biological research for nursing·2026
Same journal

Neurovascular Resilience and Autonomic Inertia: The Impact of Age and Sex on Intracranial Dynamics During Stress.

Biological research for nursing·2026
Same journal

Impact of <i>IL6</i> and <i>IL10</i> Genotype on Cytokines and Preeclampsia in a Pregnant Multi-Ethnic Cohort of Women With Overweight and Obesity.

Biological research for nursing·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2026

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
14:52

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Published on: January 13, 2018

Ascorbic acid does not influence consciousness recovery after anesthesia.

Henry C Talley V1, Mona N Wicks, Michael Carter

  • 1College of Nursing, Michigan State University, East Lansing, Michigan, USA. htalley1@comcast.net

Biological Research for Nursing
|November 20, 2008
PubMed
Summary
This summary is machine-generated.

This study investigated ascorbic acid

More Related Videos

Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
08:16

Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics

Published on: July 23, 2020

Related Experiment Videos

Last Updated: Jun 27, 2026

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
14:52

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Published on: January 13, 2018

Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
08:16

Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics

Published on: July 23, 2020

Area of Science:

  • Anesthesiology and Perioperative Medicine
  • Neuroscience and Cognitive Function
  • Biochemistry and Nutritional Science

Background:

  • General anesthesia impacts consciousness and cognitive processes, with potential effects on plasma ascorbic acid levels.
  • The relationship between ascorbic acid, general anesthesia, and postoperative consciousness recovery is not well-established.
  • Ascorbic acid's role in brain function suggests a potential link to returning consciousness post-anesthesia.

Purpose of the Study:

  • To examine changes in plasma ascorbic acid levels during general anesthesia.
  • To investigate the relationship between ascorbic acid levels and the recovery of consciousness after general anesthesia.

Main Methods:

  • A pretest-posttest repeated measures design was employed with 50 surgical patients.
  • Plasma ascorbic acid levels were measured at four time points during the anesthesia regimen.
  • Postoperative consciousness was assessed using a concentration measure.

Main Results:

  • Plasma ascorbic acid levels exhibited changes at various time points during general anesthesia in nonemergent surgical patients.
  • No statistically significant correlation was found between plasma ascorbic acid levels and enhanced post-anesthesia consciousness.
  • The study did not find evidence that ascorbic acid influences the recovery of consciousness after general anesthesia.

Conclusions:

  • While plasma ascorbic acid levels fluctuate during general anesthesia, they do not appear to significantly impact the speed of consciousness recovery.
  • Further research may be needed to explore other potential moderators or mechanisms influencing postoperative cognitive function.