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Updated: Jun 27, 2026

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

Modeling stem cell asymmetry in yeast.

P H Thorpe¹, J Bruno, R Rothstein

¹Department of Genetics and Development, Columbia University Medical Center, New York, New York 10032, USA.

Cold Spring Harbor Symposia on Quantitative Biology

|November 22, 2008

Summary

This summary is machine-generated.

Researchers found kinetochore asymmetry in yeast spores, suggesting a mechanism for nonrandom sister-chromatid segregation. This finding may explain how adult stem cells maintain their lineage during asymmetric cell division.

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Dissection of Saccharomyces Cerevisiae Asci

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Published on: May 19, 2009

Area of Science:

Cell Biology
Genetics
Microbiology

Background:

Adult stem cells require asymmetric cell division for self-renewal and differentiation.
Asymmetric cell division models involve either preferential distribution of internal factors or extrinsic signals.
Lineage-specific asymmetry has not been well-characterized in microbial systems.

Purpose of the Study:

To investigate lineage-specific asymmetry in microbial systems.
To explore the potential role of kinetochore asymmetry in stem cell biology.
To identify mechanisms for nonrandom sister-chromatid segregation in stem cell lineages.

Main Methods:

Identification of stem-cell-like kinetochore asymmetry in postmeiotic yeast spores.
Analysis of kinetochore function in chromosome segregation.
Discussion of implications for stem cell lineage maintenance.

Main Results:

A lineage-specific pattern of kinetochore asymmetry was identified in yeast spores.
This asymmetry has the potential to segregate sister chromatids nonrandomly.
A kinetochore-specific mechanism supporting lineage-specific nonrandom sister-chromatid segregation was identified in yeast.

Conclusions:

The identified yeast mechanism provides a potential model for nonrandom sister-chromatid segregation in stem cells.
This finding may offer insights into how stem cells maintain their unique lineage.
Further research is needed to fully understand the implications for adult stem cell biology.