Effect of orchiectomy on structures of the thymus expressing major histocompatibility complex class II molecules

Morphological and immunohistochemical study was performed to evaluate the effect of orchiectomy on structures of the thymus expressing major histocompatibility complex class II (MHC-II) proteins. Male sex hormone deficiency in the organism led to an increase in the number of MHC-II+ cells in the medulla and cortex of the thymic lobule. At the same time, the count of these cells in the corticomedullary zone decreased after orchiectomy. These changes modify homeostasis and activate immune processes.