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Updated: Jun 27, 2026
02:26
Intracranial Pharmacotherapy and Pain Assays in Rodents
Published on: April 9, 2019
Pain and the brain
Lesley M Arnold1, Rakesh Jain, William M Glazer
1Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
The Journal of Clinical Psychiatry
|November 26, 2008
Summary
Chronic pain and mood disorders often coexist, sharing similar pathways. Serotonin-norepinephrine reuptake inhibitors (SNRIs) and therapies can treat both pain and depression symptoms.
Area of Science:
- Neuroscience
- Psychiatry
- Pain Medicine
Background:
- Chronic pain and psychiatric conditions, particularly depression, frequently co-occur.
- Shared neurobiological pathways and neurochemical underpinnings, involving serotonin and norepinephrine, link pain and mood disorders.
- The comorbidity can complicate diagnosis and treatment of both conditions.
Purpose of the Study:
- To discuss the pathophysiology, diagnosis, and treatment of comorbid pain and mood disorders.
- To highlight the role of neurotransmitters like serotonin and norepinephrine in both conditions.
- To present case studies and expert insights on managing these complex conditions.
Main Methods:
- Review of the pathophysiology linking pain and mood disorders.
- Discussion of diagnostic challenges in comorbid cases.
- Exploration of treatment strategies including pharmacotherapy (e.g., SNRIs) and psychotherapy.
Main Results:
- Serotonin-norepinephrine reuptake inhibitors (SNRIs) show potential for managing both pain and depressive symptoms.
- Integrated treatment approaches combining medication, psychotherapy, and education are crucial for optimal patient functioning.
- Case studies illustrate the complexities of diabetic neuropathy, lower back pain, and chronic widespread pain in the context of mood disorders.
Conclusions:
- Effective management of chronic pain and comorbid mood disorders requires understanding their shared neurobiology.
- Pharmacological interventions targeting serotonin and norepinephrine, alongside psychotherapeutic approaches, offer a dual benefit.
- A comprehensive, multidisciplinary approach is essential for improving outcomes and patient functioning.
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