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Related Concept Videos

Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Hypoxia01:23

Hypoxia

Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.

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Related Experiment Video

Updated: Jun 27, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

Hypothermia for hypoxic-ischemic encephalopathy.

Rakesh Sahni1, Ulana M Sanocka

  • 1Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. rs62@columbia.edu

Clinics in Perinatology
|November 26, 2008
PubMed
Summary
This summary is machine-generated.

Hypothermia combined with other neuroprotective treatments shows promise for treating newborn infants with hypoxic-ischemic encephalopathy. Targeting multiple injury pathways may be more effective than hypothermia alone.

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A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy

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Related Experiment Videos

Last Updated: Jun 27, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
08:47

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia

Published on: November 19, 2008

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy
10:30

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy

Published on: May 16, 2015

Area of Science:

  • Neuroscience
  • Neonatal Medicine
  • Critical Care

Background:

  • Hypoxic-ischemic encephalopathy (HIE) is a serious condition in newborn infants.
  • Therapeutic hypothermia is a current standard of care for HIE.
  • Limitations exist with hypothermia monotherapy.

Purpose of the Study:

  • To explore the potential of combining hypothermia with novel neuroprotective interventions.
  • To evaluate if multi-targeted approaches improve outcomes in HIE compared to hypothermia alone.

Main Methods:

  • Review of existing literature on neuroprotective strategies.
  • Analysis of the molecular cascade of brain injury in HIE.
  • Conceptual framework for combination therapies.

Main Results:

  • Emerging neuroprotective agents target various pathways in the HIE cascade.
  • Combination therapy offers a synergistic approach to neuroprotection.
  • Multi-target interventions may overcome limitations of single-modality treatments.

Conclusions:

  • The future of HIE treatment likely involves combination therapies.
  • Targeting multiple sites of injury presents a promising strategy for improved infant outcomes.
  • Further research into combined hypothermia and novel interventions is warranted.