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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview

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Related Experiment Video

Updated: Jun 27, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Fetomaternal immunotolerance.

Antonis Makrigiannakis1, Maria Karamouti, Petros Drakakis

  • 1Laboratory of Human Reproduction, Department of Obstetrics and Gynaecology, Medical School, University of Crete, Heraklion, Greece. makrigia@med.uoc.gr

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|November 27, 2008
PubMed
Summary
This summary is machine-generated.

Successful pregnancy relies on complex implantation processes, yet many losses occur early. Understanding the molecular and physiological roadmap of implantation is key to treating fertility defects and ensuring successful reproduction.

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A Mouse Model of in Utero Transplantation
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A Mouse Model of in Utero Transplantation

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A Mouse Model of in Utero Transplantation
09:11

A Mouse Model of in Utero Transplantation

Published on: January 27, 2011

Area of Science:

  • Reproductive biology and immunology
  • Developmental biology
  • Maternal-fetal medicine

Background:

  • Implantation is a critical, evolutionarily refined process for mammalian reproduction.
  • A significant proportion of pregnancy failures occur during the peri-implantation period.
  • Decoding implantation mechanisms is essential for addressing infertility.

Purpose of the Study:

  • To elucidate the molecular and physiological factors governing successful embryo implantation.
  • To identify key elements of feto-maternal cross-talk crucial for implantation.
  • To provide insights into potential targets for treating implantation-related fertility defects.

Main Methods:

  • Analysis of molecular and immunological factors at the feto-maternal interface.
  • Investigation of hormonal and cytokine signaling during implantation.
  • Examination of cell-surface antigen expression (e.g., MHC, Fas/FasL) in human trophoblast.

Main Results:

  • Identified atypical expression patterns of major histocompatibility complex (MHC) and other antigens (Fas/FasL, petformin) in human trophoblast.
  • Demonstrated modified functions of cellular components at the feto-maternal interface.
  • Highlighted the specific roles of hormones and cytokines in mediating feto-maternal immunotolerance.

Conclusions:

  • Successful implantation depends on intricate feto-maternal immunotolerance.
  • Specific molecular (MHC, Fas/FasL) and hormonal factors are critical for successful pregnancy establishment.
  • Further research into these parameters can lead to improved fertility treatments.