[Preliminary investigation of effect of pyocyanin on common bacteria in burn wound]

Pyocyanin was extracted from culture medium of Ps. aeruginosa by Frank's method. Minimum inhibitory concentration (MIC) & minimum bactericidal concentration (MBC) of pyocyanin for 6 species of bacteria isolated from burn wounds were determined. The results of MIC & MBC: S. aureus 12.5 micrograms/ml, 50 micrograms/ml; E. coli 25 micrograms/ml, 100 micrograms/ml; P. vulgaris 50 micrograms/ml, 200 micrograms/ml; C. freundii 100 micrograms/ml, 400 micrograms/ml; S. epidermidis 12.5 micrograms/ml, 50 micrograms/ml; no inhibitory effect on Ps. aeruginosa. According to the laboratory results and clinical findings, the authors believe that when there is a dominant growth of Ps. aeruginosa in burn wounds there may be pyocyanin production to inhibit or kill other species of bacteria.