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Prostaglandins and NSAID in the kidney.
1International Medical Operations, Searle, Skokie, IL 60077.
The Journal of Rheumatology. Supplement
|March 1, 1991
Summary
Nonsteroidal anti-inflammatory drugs (NSAID) can harm kidney function by inhibiting prostaglandin synthesis. Misoprostol may prevent NSAID-induced kidney damage and reduce rejection in renal transplant patients.
Area of Science:
- Nephrology
- Immunology
- Pharmacology
Background:
- Nonsteroidal anti-inflammatory drugs (NSAID) can impair renal function by inhibiting prostaglandin (PG) synthesis.
- Exogenous prostaglandins, like misoprostol, may offer protective effects against NSAID-induced nephrotoxicity.
- Misoprostol also exhibits immunomodulatory properties.
Purpose of the Study:
- To investigate the potential of misoprostol in preventing NSAID-induced nephrotoxicity.
- To evaluate the effects of misoprostol on graft rejection and function in renal transplant patients receiving immunosuppressive therapy.
Main Methods:
- Administration of NSAID to patients with renal impairment.
- Administration of misoprostol to assess its protective effects against NSAID-induced nephrotoxicity.
- Observational study of renal transplant patients receiving misoprostol, cyclosporine, and prednisone.
Main Results:
- Misoprostol partially prevented NSAID-induced reduction in renal function.
- In renal transplant patients, misoprostol use was associated with reduced acute graft rejection.
- Improved graft function was observed in patients receiving misoprostol, regardless of rejection occurrence.
Conclusions:
- Exogenous prostaglandins, specifically misoprostol, may play a role in mitigating NSAID-induced renal impairment.
- Misoprostol demonstrates potential benefits in renal transplant recipients, including reduced rejection and improved graft function.
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