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Updated: Jun 27, 2026

Hydrogen Production and Utilization in a Membrane Reactor
Published on: March 10, 2023
Intraluminal hydrogen peroxide induces a permeability change of the endoplasmic reticulum membrane
Eva Margittai1, Péter Löw, András Szarka
1Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University and MTA-SE Pathobiochemistry Research Group, PO Box 260, 1444 Budapest, Hungary.
Abstract:
Gulonolactone treatment of mice resulted in the elevation of hepatic ascorbate and hydrogen peroxide levels accompanied by transient liver swelling and reversible dilatation of endoplasmic reticulum cisternae. Although a decrease in glutathione (reduced form)/total glutathione ratio was observed in microsomes, the redox state of luminal foldases remained unchanged and the signs of endoplasmic reticulum stress were absent. Increased permeability of the microsomal membrane to various compounds of low molecular weight was substantiated. It is assumed that Gulonolactone-dependent luminal hydrogen peroxide formation in the endoplasmic reticulum provokes a temporary increase in non-selective membrane permeability, which results in the dilation of the organelle and in enhanced transmembrane fluxes of small molecules.
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