Related Experiment Video
Updated: Jun 27, 2026
Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
Published on: August 24, 2015
Noninfectious transfusion of platelets donated before detection of human immunodeficiency virus RNA in plasma
Ulrich Kalus1, Anke Edelmann, Axel Pruss
1Institute of Transfusion Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany. ulrich.kalus@charite.de
Background:
It is unknown whether human immunodeficiency virus (HIV) can be transmitted via blood products donated after primary HIV-1 infection before the detection of viral RNA in plasma.
Case Report:
From a 39-year-old repeat donor, double plateletpheresis donations were collected on Days 4 and 18 after the presumptive date of primary HIV-1 infection. The former apheresis donations tested negative for the presence of HIV and were transfused to two patients, whereas the latter donation tested positive by reverse transcription-polymerase chain reaction (RT-PCR) but not in antibody screening and was not released for transfusion.
Results:
One of the recipients of the Day 4 apheresis donation died of unrelated reasons and could therefore not be tested. The second recipient did not develop HIV-1 infection and has remained negative for the presence of all HIV markers over a period of 7.5 months after the receipt of the apheresis unit. In the donor, qualitative and quantitative RT-PCR as well as an antibody-antigen combination assay were observed to be positive on Day 18. In contrast, the HIV antibody screening test became positive for the first time on Day 25.
Conclusion:
Transmission of HIV-1 may not occur during the very early stage of infection.
