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Related Concept Videos

Structure of Cadherins01:25

Structure of Cadherins

The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This diversity of cadherins...
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Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
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Regulation of Angiogenesis and Blood Supply

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
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Updated: Jun 27, 2026

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

Breaking the VE-cadherin bonds.

Julie Gavard1

  • 1Institut Cochin, Universite Paris Descartes, CNRS (UMR 8104), Paris, France. julie.gavard@inserm.fr

FEBS Letters
|December 9, 2008
PubMed
Summary
This summary is machine-generated.

Vascular endothelial cadherin (VE-cadherin) is crucial for blood vessel integrity. Permeability-inducing factors destabilize VE-cadherin, while anti-factors stabilize it, impacting vascular wall remodeling and angiogenesis.

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Related Experiment Videos

Last Updated: Jun 27, 2026

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

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Real-time Imaging of Endothelial Cell-cell Junctions During Neutrophil Transmigration Under Physiological Flow
11:26

Real-time Imaging of Endothelial Cell-cell Junctions During Neutrophil Transmigration Under Physiological Flow

Published on: August 14, 2014

Area of Science:

  • Endothelial biology
  • Vascular physiology
  • Cell adhesion

Background:

  • Endothelial barrier function regulates blood-tissue exchange.
  • VE-cadherin is a key endothelial cell-cell adhesion molecule.
  • VE-cadherin is vital for vascular wall formation, maturation, and remodeling.

Purpose of the Study:

  • To investigate the role of VE-cadherin in endothelial barrier regulation.
  • To explore the impact of permeability-inducing factors (PIFs) and anti-PIFs on VE-cadherin.
  • To understand how endothelial cell-cell junctions influence vascular networks and angiogenesis.

Main Methods:

  • Analysis of signaling mechanisms triggered by PIFs.
  • Assessment of VE-cadherin stability and junctional architecture.
  • Evaluation of the effects of anti-PIFs on endothelial cell cohesion.

Main Results:

  • PIFs induce signaling pathways that destabilize VE-cadherin.
  • VE-cadherin destabilization leads to altered junctional architecture.
  • Anti-PIFs prevent VE-cadherin disruption and improve cell cohesion.

Conclusions:

  • Endothelial cell-cell junctions, regulated by VE-cadherin, are critical for vascular integrity.
  • VE-cadherin dynamics are central to controlling vascular permeability.
  • Understanding these mechanisms offers new insights into normal and aberrant angiogenesis.