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Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
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Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

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Meniscus replacement using synthetic materials.

Tony G van Tienen1, Gerjon Hannink, Pieter Buma

  • 1Orthopedic Research Laboratory, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands. t.vantienen@orthop.umcn.nl

Clinics in Sports Medicine
|December 10, 2008
PubMed
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Meniscal implants can prevent knee osteoarthritis after total meniscectomy. Current research focuses on tissue engineering and cell-seeding techniques for meniscal substitutes.

Area of Science:

  • Orthopedics
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • The meniscus is vital for knee joint function, load transmission, and stability.
  • Meniscus loss leads to joint degeneration and osteoarthritis.
  • Preserving meniscal tissue via repair or partial resection is preferred, but total meniscectomy is sometimes necessary.

Purpose of the Study:

  • To review current research on meniscal substitutes for total meniscectomy.
  • To highlight the potential of implants in preventing post-meniscectomy osteoarthritis.
  • To identify trends in meniscal tissue engineering.

Main Methods:

  • Review of experimental and clinical studies on meniscal substitutes.
  • Analysis of different implant types: allografts, collagen, synthetic scaffolds (permanent and biodegradable).

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Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
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Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

  • Focus on current research trends, particularly tissue engineering approaches.

    • Main Results:

    • Various meniscal substitutes have been investigated, including allografts and synthetic scaffolds.
    • Tissue engineering, with or without cell seeding, is a primary focus of current research.
    • Implants aim to replace resected meniscal tissue and prevent articular cartilage degeneration.

    Conclusions:

    • Meniscal implants offer a potential solution to avoid osteoarthritis after total meniscectomy.
    • Biological tissue-engineering approaches are the leading area of investigation for meniscal substitutes.
    • Further research into effective meniscal replacement strategies is crucial for knee joint preservation.