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Updated: Jun 27, 2026

A High Output Method to Isolate Cerebral Pericytes from Mouse
Published on: January 14, 2020
Pericyte signaling in the neurovascular unit
1Department of Neurology, UC Irvine Medical Center, 101 The City Drive South, Shanbrom Hall, Room 121, Orange, CA 92868, USA. mfisher@uci.edu
Abstract:
Brain pericytes are intimately associated with capillary endothelial cells, separated only by basement membrane. Pericyte research has been hampered by absence of pericyte-specific immunochemical markers. The vast array of pericyte functions include contractility, immunologic, migratory, and angiogenic. Pericytes have stem cell potential, contribute to the integrity of the blood-brain barrier, and have a regulatory role for hemostasis in the brain. Improvement in pericyte identification is likely to lead to marked increase in appreciation of the role of pericytes in the neurovascular unit.
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