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Updated: Jun 27, 2026
06:19
Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease
Published on: October 20, 2023
Blood-brain barrier function in intracerebral hemorrhage
1Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109-2200, USA. rkeep@umich.edu
Acta Neurochirurgica. Supplement
|December 11, 2008
Summary
Intracerebral hemorrhage (ICH) causes blood-brain barrier (BBB) dysfunction, leading to brain injury. Targeting multiple pathways or common pathways may prevent ICH-induced BBB disruption.
Area of Science:
- Neuroscience
- Pathology
Background:
- Blood-brain barrier (BBB) dysfunction is a key feature of intracerebral hemorrhage (ICH)-induced brain injury.
- BBB disruption contributes to edema, leukocyte infiltration, and entry of neuroactive substances into the brain.
Purpose of the Study:
- To review current knowledge on BBB dysfunction following ICH.
- To explore factors contributing to BBB disruption and potential therapeutic strategies.
Main Methods:
- Literature review of studies on BBB dysfunction in ICH.
- Analysis of factors implicated in BBB disruption, including inflammatory mediators, thrombin, and oxidative stress.
Main Results:
- ICH-induced BBB disruption involves multiple factors like cytokines, thrombin, and matrix metalloproteinases.
- While passive permeability changes are well-studied, effects on BBB transport and metabolic functions are less understood.
- ICH may affect BBB transport, potentially offering protection in smaller hemorrhages.
Conclusions:
- Preventing ICH-induced BBB disruption may require targeting multiple pathways or a common end pathway.
- BBB disruption's role in ICH may be context-dependent, potentially beneficial in small bleeds but detrimental in larger ones.
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