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Lanostane-type triterpenes from the mushroom Astraeus pteridis with antituberculosis activity
Rita Stanikunaite1, Mohamed M Radwan, James M Trappe
1Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.
Journal of Natural Products
|December 11, 2008
Summary
Researchers isolated new lanostane triterpenes from the mushroom Astraeus pteridis. Two compounds showed moderate activity against Mycobacterium tuberculosis, offering potential leads for new drug discovery.
Area of Science:
- Natural Products Chemistry
- Mycology
- Medicinal Chemistry
Background:
- The mushroom Astraeus pteridis, resembling a truffle, is a potential source of novel bioactive compounds.
- Lanostane triterpenes are a class of natural products with diverse biological activities.
- Mycobacterium tuberculosis remains a significant global health threat, necessitating the search for new anti-tubercular agents.
Purpose of the Study:
- To isolate and characterize chemical constituents from Astraeus pteridis.
- To evaluate the isolated compounds for anti-tubercular activity.
Main Methods:
- Bioassay-guided fractionation of an ethanol extract of Astraeus pteridis.
- Structure elucidation using 1D and 2D NMR spectroscopy, HRESIMS, and X-ray crystallography.
- Determination of minimum inhibitory concentration (MIC) against Mycobacterium tuberculosis.
Main Results:
- Three new and two known lanostane triterpenes, along with phenylalanine betaine, were isolated.
- Compounds 5 and 1 exhibited moderate activity against Mycobacterium tuberculosis.
- MIC values for compounds 5 and 1 were 34.0 and 58.0 microg/mL, respectively.
Conclusions:
- Astraeus pteridis is a source of novel lanostane triterpenes.
- Compounds 5 and 1 demonstrate potential as starting points for developing new anti-tubercular drugs.
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