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Updated: Jun 27, 2026
12:27
A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
Published on: June 8, 2022
Targeting sphingosine-1-phosphate signalling for cardioprotection
Simon Kennedy1, Kathleen A Kane, Nigel J Pyne
1Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK. s.kennedy@bio.gla.ac.uk
Current Opinion in Pharmacology
|December 17, 2008
Summary
Sphingosine-1-phosphate (S1P) acts as a survival factor, offering cardioprotection by pre-conditioning and post-conditioning the heart. Its presence in high-density lipoprotein (HDL) contributes to HDL
Area of Science:
- Cardiovascular Biology
- Molecular Pharmacology
Background:
- Sphingosine-1-phosphate (S1P) is a bioactive lysophospholipid.
- S1P is generated by sphingosine kinases (SK1/SK2) and circulates bound to HDL or albumin.
- S1P mediates its effects via five G protein-coupled receptors (GPCRs), S1P1-5.
Purpose of the Study:
- Investigate the role of S1P as a cardioprotective agent.
- Explore the mechanisms underlying S1P-mediated cardiac protection.
- Examine the link between S1P, HDL, and cardiovascular health.
Main Methods:
- Review of existing literature on S1P signaling in the cardiovascular system.
- Analysis of studies investigating S1P's effects on cardiac tissue.
- Exploration of the relationship between S1P, HDL, and cardioprotection.
Main Results:
- S1P is present in cardiac tissue and acts as a survival factor.
- S1P demonstrates cardioprotective effects through pre-conditioning and post-conditioning.
- The cardioprotective properties of HDL may be attributed to its S1P content.
- Emerging evidence suggests a link between cannabinoid and S1P cardioprotective effects.
Conclusions:
- S1P is a significant factor in cardiovascular protection.
- S1P signaling pathways represent potential therapeutic targets for heart disease.
- Further research is warranted to elucidate the full cardioprotective potential of S1P and its interactions.
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